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Adenosine

Adenosine is an endogenous purine nucleoside, which can slow down the atrioventricular node conduction, block the atrioventricular node reentry pathway, and patients with paroxysmal supraventricular tachycardia (PSVT) (with or without pre-excitation syndr
Product parameters
Trade Name: Coenzyme ADE
Product Name: Adenosine
CAS No.: 58-61-7
Form: Powder
Assay: 98%min
Certification: ISO9001; ISO 14001; ISO 18001
Packing Sizes: 25KG
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Description
Adenosine 
 
Adenosine is a type of nucleoside, each consisting of ribose (ribofuranose) and a part of adenine, and the middle is connected by β-N9-glycosidic bond.
 
Adenosine plays an important role in biochemistry, including energy transfer in the form of Adenosine triphosphate (ATP) or Adenosine diphosphate (ADP), or signal transmission in the form of cyclic Adenosine monophosphate (cAMP). In addition, Adenosine is also an inhibitory neurotransmitter (inhibitory neurotransmitter), which may promote sleep.  
 
Adenosine is an endogenous purine nucleoside, which can slow down the atrioventricular node conduction, block the atrioventricular node reentry pathway, and patients with paroxysmal supraventricular tachycardia (PSVT) (with or without pre-excitation syndrome) Restore normal sinus rhy-thm. Adenosine can be quickly taken up by red blood cells, so the action time is very short, and the plasma half-life of free Adenosine is less than 10s.
 
The most common form of PSVT is through the reentrant pathway, so Adenosine can effectively terminate this type of arrhyt-hmia. For non-atrioventricular node or sinoatrial node reentrant arrhy-thmia (such as atrial flutter, atrial fibrillation, atrial tachycardia, ventricular tachycardia), Adenosine cannot stop it, but it can produce temporary atrioventricular or ventricular block, which is helpful To make a differential diagnosis.
 
The indication for Adenosine is to convert PSVT (with or without pre-excitation syndrome) to sinus rhy-thm. Due to the short half-life of Adenosine, PSVT can relapse. Repeated injections can be used to treat recurrent PSVT, but verapamil and diltiazem have a longer action time. If there are no contraindications (such as pre-excitation syndrome), it is preferable.
 
Clinically, the recommended dose of Adenosine is 6 mg a dose of intravenous bolus injection within 1 to 3 seconds, followed by infusion of 20 ml of normal saline. There is often a short cardiac pause (up to 15s) after rapid administration. If there is no response within 1 to 2 minutes after injection, there is limited experience in giving a higher dose of 12 mg. People taking theophylline are less sensitive to Adenosine and may require larger doses.
 
The side effects of Adenosine (flushing, shortness of breath, chest pain) are common, but most of them are transient (disappear within 1 to 2 minutes). Short-term sinus bradycardia and premature ventricular beats are common after the termination of the supraventricular. Therefore, it should be used with caution for those with sinus bradycardia or atrioventricular block. Due to the short action time of Adenosine, it has little effect on hemodynamics and rarely causes hypotension. Adenosine interacts with certain drugs. Theophylline at therapeutic concentrations can block the receptors that Adenosine depends on for its electrophysiological and hemodynamic effects. Dipyridamole (pensantin) blocks the uptake of Adenosine, thereby enhancing its effect. For patients who are taking these drugs, other drugs should be used to treat arrhy-thmia.
 
Adenosine is the key to deep brain stimulation
In the December 23 issue of the journal Nature Medicine, a new study showed that a brain compound that helps us sleep is effective in relieving deep brain stimulation in patients with Parkinson’s disease and other encephalopathy. Whether it’s important.
 
This study shows that a brain compound that can induce drowsiness-Adenosine is the key to the effect of deep brain stimulation (DBS). This technique is used to treat Parkinson's disease and patients with severe tremor. This method has also been tried to treat patients with severe depression.
 
Patients usually need to install a kind of "brain pacemaker"-a small transplant device that can transmit the designed electronic signal to the precise location of the patient's brain. This process interrupts abnormal nerve signals and can relieve symptoms. However, there is still controversy as to how exactly this process occurs.
 
This new study conducted by researchers at the University of Rochester Medical Center has discovered an unexpected effect of Adenosine and new information about astrocytes.  
 
Applications
Adenosine is an endogenous nucleoside that can be found throughout human cells. It can directly enter the myocardium to generate adenylate through phosphorylation, which participates in myocardial energy metabolism. It also participates in dilating coronary blood vessels and increasing blood flow. Adenosine has physiological effects on the cardiovascular system and many other systems and tissues of the body. Adenosine is an important intermediate used to synthesize Adenosine triphosphate (ATP), adenine, adenylate, and arabino Adenosine.  
 
Adenosine has an anti-aging effect in cosmetics, and Adenosine is used as an antioxidant, skin conditioner, and moisturizer in cosmetics. Adenosine is an anti-aging body that can replenish skin energy, significantly improve skin elasticity, promote skin cell metabolism, prevent skin tissue relaxation, reorganize skin structure, and restore skin elasticity by tightening and narrowing pores.