Centella Asiatica Extract

In cosmetics, Centella Asiatica Extract can promote the synthesis of fibroblasts and collagen cells, and has antibacterial, anti-inflammatory and other functions.
Centella asiatica(l.) is a dry whole grass of the umbelliferae family centella asiatica(l.). Native to india, it is widely distributed in tropical and subtropical regions of the world, and mainly distributed in the provinces south of the yangtze river in china. The centulae plant grows in wet banks, swamps, and meadows. In china, centella asiaticawas first recorded in the shennong herba sutras, indicating that it has a long history of medicinal use in china.
"Chinese pharmacopoeia" Since 1977 edition, after the edition of the pharmacopoeia have been included, centella centella has the effect of clearing heat detoxification, swelling and wetness. Used for hot and humid jaundice, heat stroke diarrhea, sand dripping blood, carbuncle swelling sore poison, fall injury.
The umbelliferae centulata plant is tender in texture, good palatability, and can be eaten raw. Folk people in southern china are often used to treat colds, tonsillitis, infectious hepatitis, dysentery, bruxism, sores, wounds and bleeding, etc. Centella is also eaten as a vegetable in southeast asia, india, pakistan, sri lanka and south america. Centella has long been used as a traditional medicine in india, asia and africa (such as madagascar), mainly to treat skin and mucous membrane diseases. According to legend, the bengal tiger rolls on the grass to heal its wounds, so the plant is also called "Tiger grass" In india. Its pharmacological properties also vary from region to region. Modern pharmacology study, Centella Asiatica Extract has stronger of the central nervous inhibition and anti gastric ulcer, anti-cancer, anti-inflammatory, enhance memory and improve cardiovascular pharmacological effects, in cosmetics, Centella Asiatica Extract can promote the synthesis of fibroblasts and collagen cells, and has antibacterial, anti-inflammatory and other functions.
1. Main chemical components in Centella Asiatica Extract
Modern studies have shown that Centella Asiatica Extract contains a variety of triterpenoid components of n-aromatic resin alcohol, including asiaticoside, sankum nitin, isopankum nitin, madecassoside, glucoside, demergic glycoside and demergic acid, as well as matica. In addition, it contains meso inositol, centella sugar (an oligosaccharide), wax, carotene hydrocarbons, chlorophyll, and the flavonoid glycosides of kaempferol, quercetin, glucose and rhamnose. Triterpenoid acid and triterpenoid saponins are mainly contained in whole grass. Triterpenes include cisteric acid, hydroxy cisteric acid, isohydroxy cisteric acid and betulinic acid. Triterpenoid saponins include asiaticoside, hydroxy asiaticoside, triglycoside and tetraglycoside. It also contains kaempferin, quercetin and its glycosides, centussin, meso inositol, centussin oligosaccharide, sitosterol, vitamin c, carotene, green volatile oil and resinous substances.
The main active components of Centella Asiatica Extract can be used in cosmetics are asiatic acid and madecassic acid, asiaticoside and madecassoside.
2. Application of Centella Asiatica Extract in cosmetics
2.1 Antibacterial activity of Centella Asiatica Extract
The extract contains asiatic acid and madecassic acid, which are active saponins that acidify the cytoplasm of plant cells. This antibacterial activity protects the plant against mold and yeast. The results showed that the Centella Asiatica Extract had a certain inhibitory effect on pseudomonas aeruginosa, staphylococcus aureus, and acneobacter acnes. Taking advantage of this, Centella Asiatica Extract can be used to treat acne or in disposable hygiene products.
2.2 Anti-inflammatory activity of Centella Asiatica Extract
Centella Asiatica Extract can reduce the production of pre-inflammatory mediators (il 21,mmp21), improve and repair the skin's own barrier function, thus preventing and correcting skin immune dysfunction. A controlled experiment was conducted on total asiaticoside and dexamethasone, including cotton ball granuloma in rats and ear swelling induced by xylene in mice, which proved that total asiaticoside had significant anti-inflammatory effect. Centella asiatica also has antibacterial and antiviral effect of staphylococcus aureus and proteus has bacteriostatic action, yu2jen chen et al. [3] is found, Centella Asiatica Extract to 16 mg/cm2 skin dosage, to the three different intensity of radiation to the mice skin damage with different degree of therapeutic effect, and the western han has a plain proof (tetran2 drine) the treatment effect of no significant difference, but ahead of sinomenium acutum has a element (tetrandrine) 12 ~ 15 days began to lighten the skin reaction, suggests Centella Asiatica Extract has anti-inflammatory activity. Using this characteristic of Centella Asiatica Extract, we can apply it to repair after sunburn, anti-allergy and soothing cosmetics.
2.3 Centella Asiatica Extract can promote the synthesis of fibroblasts and collagen
After more than 20 years of scientific research found, Centella Asiatica Extract can promote the synthesis of collagen Ⅰ and Ⅲ, at the same time also can promote the secretion of glycosaminoglycan (e.g., the synthesis of hyaluronic acid), increase skin moisture-retaining ability, update activation of skin cells, make skin soothing, promotion, and rich burnish feeling; on the other hand, the cDNA alignment test also found that Centella Asiatica Extract also has the activation effect of fibroblast genes, which can enhance the vitality of skin cells in the basal layer, maintain the skin elasticity and tight feeling, and smooth the fine wrinkles of the face. Lv luo, wei shaomin [4] etc. Through the experiment also found that they used different doses of Asiaticosides and Madecassoside in cultured fibroblasts (hum an skin fi2 b rob last, hsfb), by ria method of determination of the experimental group and blank control group on cells in supernatant Ⅰ type collagen peptide amino end before the original (p Ⅰ np) and type Ⅲ collagen peptide amino end before the original (p Ⅲ np) content. The results showed: (1) compared with the blank control group, Asiaticosides and Madecassoside can effectively stimulate the in vitro cultivation of HSFb PⅠNP and PⅢNP secretion; (2) The biological effects of Asiaticosides and Madecassoside on the secretion of P Ⅰ NP and P Ⅲ NP in target cells showed a significant dose-response relationship; (3) in 10 mu mu g/g/ml to 150 ml dose, ad of hsfb stimulate the secretion of P Ⅰ NP showed stronger than md biological activity (p < 0.01). The results showed that Centella Asiatica Extract could significantly promote the synthesis of fibroblasts and collagen.
The pharmacological studies made by domestic and foreign scholars showed that the Centella Asiatica Extract had excellent healing effect on wounds and scars, and the reason was that Asiaticoside had important effects on collagen synthesis, new angiogenesis and granulation growth in vivo, so it was beneficial to wound healing. If the preparation containing asiaticoside is applied continuously on the skin wound surface, it can prevent wound infection and fester, shorten wound healing time, reduce skin hardness and improve skin nutrition, and promote metabolism. Pan et al. [6] cultured human scar fibroblasts by tissue block method, and used flow cytometry to detect the changes in cell cycle and phosphorylation of smad2 and smad7 under normal conditions and after the application of asiaticoside. The results showed that the effect of asiaticoside on scar inhibition could pass through the smad pathway. Derived from natural Centella Asiatica Extract, commonly known as "Plant collagen", it is ideal for the treatment of damaged skin. Bayer tested 40 women volunteers with stretch marks on the double blind, using an oil/water/oil formula containing 1% Centella Asiatica Extract twice a day for three months.
The experimental results are shown in table 1:
Table 1 experimental results of oil/water/oil formula containing 1% Centella Asiatica Extract
Stretch mark width Stretch mark length Stretch mark color
(compared with blank group)
(compared with blank group)
(compared with blank group)
The company's tests have also shown that Centella Asiatica Extract can speed up the healing process and shorten the healing time
40%; it can also prevent stretch marks during pregnancy.
2.4 other functions of Centella Asiatica Extract
Centella Asiatica Extract also has a strong antioxidant effect, can inhibit free radical activity, reduce melanosis, improve skin blood circulation, renew skin cell regeneration, help melanin metabolism out of the body, after use, skin smooth, delicate, white and beautiful.