Coenzyme Q10
Coenzyme Q10 is a fat-soluble antioxidant. Coenzyme Q10 is one of the indispensable and important elements of human life. It can activate human cells and cell energy nutrition, improve human immunity, enhance anti-oxidation, delay aging and enhance human vitality, etc. Functionally, it is widely used in cardiovascular diseases in medicine, and it is widely used in nutrition and health products and food additives at home and abroad. Coenzyme Q10 was first discovered in the United States in 1957. In the same year, Dr. Peter Mack from the University of Edinburgh won the Nobel Prize for his contribution to the study of the relationship between Coenzyme Q10 and cell energy. Coenzyme Q10 is relatively high in foods such as organs (heart, liver, kidney), beef, soybean oil, sardines, mackerel, and peanuts. Ingestion of about 1 catty of sardines, 2 catties of beef or 3 catties of peanuts can provide about 30mg Coenzyme Q10.
Coenzyme Q10 was discovered in 1957. In 1958, it was identified by Dr. Caru Flucas for its chemical structure, and won the Priestly Medal, the highest honor of the American Chemical Society. It was called the father of research on Coenzyme Q10. At that time, he proposed Coenzyme Q10. Plays an important role in heart function. In real life, Dr. Karufurukas has been taking Q10 for 40 years until his death at the age of 91. As an active professor, he has always been energetic in scientific research activities.
Functions and Applications
1, Anti-Aging
Coenzyme Q10 has two main functions in the body. One is to play an important role in the process of converting nutrients into energy in the mitochondria, and the other is to have an obvious anti-lipid peroxidation effect. It is an energy conversion agent in cell mitochondria. It participates in the "tricarboxylic acid cycle" by transferring and transferring electrons to produce ATP (adenosine triphosphate), which is an energy factor for cell metabolism. When human beings are 20 years old, the ability to synthesize coenzyme Q10 on their own reaches the peak and remains around 50 years old. It will decrease year by year in the future, because the mitochondrial DNA material of the cells hosting Coenzyme Q10 is destroyed by oxygen free radicals, resulting in a decrease in the self-synthesis of Coenzyme Q10. As a result, the metabolic function of human cells, especially heart cells, declines, and the "old age" appears.
Experiments have proved that coenzyme Q10 in the body can directly react with peroxide free radicals after it becomes alcoholic, and can regenerate vE, independently and synergistically with vE to play an antioxidant role. In vitro experiments have also found that the antioxidant Coenzyme Q10 can protect mammalian cells from apoptosis caused by mitochondrial oxidative stress, while tumor necrosis factor-(TNF-) or oncogene suppressors have no such effect. Clinical studies have shown that oral coenzyme Q10 can protect mammalian cells from apoptosis caused by mitochondrial oxidative stress. Q10 has a significant effect on the treatment of neurodegenerative diseases related to mitochondrial dysfunction and aging such as Parkinson's disease, Huntington's disease and Alzheimer's disease.
Experiments on the relationship between aging and mitochondrial coenzyme Q10 concentration show that the decrease of mitochondrial coenzyme Q10 concentration is an important aspect of skeletal muscle aging. An experimental study on aging in rats showed that the content of coenzyme Q10 in the mitochondria of the heart of aging rats decreased, and the content in the liver and skeletal muscle was lower. The decline in immune function with age is the result of free radicals and free radical reactions. Coenzyme Q10 is an effective antioxidant and free radical scavenger. As a component of the mitochondrial respiratory chain, it is embedded in the mitochondrial inner membrane lipid bi-molecules, and it becomes the two electrons received from mitochondrial complex I or complex II. Alcohol form, and then transfer electrons to complex III. Coenzyme Q10 in the body is consumed in large quantities and becomes alcoholic. It is not only an effective antioxidant, but also an electron carrier for exercise. It transfers hydrogen atoms from its hydroxyl group to lipid peroxidation free radicals, thereby reducing lipid peroxidation in the inner mitochondrial membrane. Oxide reaction. In this process, free radical ubiquinone, which is disproportionate to the alcohol form of coenzyme Q10 and coenzyme Q10, is generated, or reacts with oxygen to form superoxide. The free radical ubiquinone is involved in superoxide dismutase and catalase. Under the action of, transport free radicals to achieve detoxification, so that the repetitive respiratory chain continuously regenerates Coenzyme Q10 into alcohol form, restoring its antioxidant activity.
The decline of immune function with age is the result of the reaction of free radicals and free radicals. Coenzyme Q10 as a strong antioxidant can be used alone or in combination with vitamin B6 (pyridoxine) to inhibit the effects of free radicals on the receptors and cells on immune cells. The modification of microtubule system related to differentiation and activity strengthens the immune system and delays aging.
The increase in wrinkles and skin aging are related to the content of Q10. The lower the content, the easier the skin will age and the more facial wrinkles. Q10 can be taken by mouth. When the cells contain enough Q10, energy metabolism will be enhanced, free radicals will be eliminated, and wrinkles will be relieved.
In addition, you can also rub skin care products containing Coenzyme Q10, and improving external use can also increase the absorption of Coenzyme Q10 by cells, thereby reducing the formation of wrinkles.
2, Anti-fatigue
In the mid-1970s, Mitchell's chemical permeation hypothesis revealed the energy conversion in organisms and the important role of coenzyme Q10 in the mitochondrial energy conversion system.
Coenzyme Q10 is the coenzyme of at least 3 kinds of mitochondrial enzymes (multi-enzyme complex I, II and III). Its chemical structure is 2,3 dimethoxy with a side chain of ten units of isoprene attached to the 6th carbon. 5-methyl 1,4-benzoquinone derivative.
The quinone ring plays the role of transferring electrons and protons in the oxidative respiratory chain. This role is not only indispensable for all life forms, but also the key to the formation of ATP. ATP is the main form of energy storage in the body, and it is also an important basis for the normal functioning of all cell functions. Coenzyme Q102.2 detection wavelength: 275nm biological activity mainly comes from the redox properties of its quinone ring and the physical and chemical properties of its side chain . It is a natural antioxidant and cell metabolism initiator produced by the cell itself. It has the function of protecting and restoring the integrity of the biomembrane structure and stabilizing the membrane potential. It is a non-specific immune enhancer of the body, so it shows excellent anti-fatigue effects. Q10 keeps cells in a good and healthy state, so the body is full of vitality, energetic, and full of brain power.
3, Anti-oxidation
The etiology and pathology of Chronic Fatigue Syndrome (CFS) are still unclear. Studies have shown that oxidative stress is a cause of the disease. Experiments have found that patients with CFS have different degrees of oxidative stress, although it is oxidative The cause or effect of the disease needs further observation, but the antioxidant coenzyme Q10 has been successfully used to prevent and treat chronic fatigue syndrome.
In addition, the antioxidant properties of Coenzyme Q10 make it have a certain inhibitory effect in the formation and development of atherosclerosis. Moreover, its antioxidant properties make membranes stable, metabolically strong heart and reverse left ventricular hypertrophy, etc., and it has been widely used in cardiovascular diseases.
4, Antitumor
Studies have shown that Coenzyme Q10 has anti-tumor effects, and has certain clinical effects on advanced metastatic cancer. It is effective in preventing coronary heart disease, relieving periodontitis, treating duodenal ulcer and gastric ulcer, enhancing human immune function and relieving angina pectoris. Significant effect.
5, Safety
Because Coenzyme Q10 is an OTC product in the US and European markets, and there are many well-designed clinical trials that show that oral coenzyme Q10 is beneficial to a variety of cardiovascular diseases, so based on its efficacy and safety and reliability characteristics, even for a long time , Oral high-dose coenzyme Q10, patients can also tolerate it well.
6, Antihypertensive
Significant research conducted by the Argentine Institute of Neuroscience has shown that in hypertensive patients, oral administration of 100 mg of coenzyme Q10 within an hour can enhance brain treatment and agility.
7, Protect the skin
Local experiments have shown that skin collagen's ability to resist damage from oxidative irritants such as ultraviolet rays decreases with age, and long-term use of Coenzyme Q10 can effectively prevent skin photoaging and reduce wrinkles around the eyes, because Coenzyme Q10 penetrates into the skin growth layer. Weaken the oxidation reaction of photons. With the assistance of tocopherol, specific phosphorylation tyrosine kinase can be activated to prevent oxidative damage of DNA, inhibit the expression of COLLA-GENASE in human skin fibroblasts under ultraviolet light, and protect the skin from damage. Extensive research suggests that Coenzyme Q10 inhibits lipid peroxidation, reduces the generation of free radicals, protects the active center of SOD and its structure from free radical oxidative damage, improves the activity of SOD and other enzymes in the body, and inhibits cell apoptosis induced by oxidative stress. , Has significant anti-oxidation and anti-aging effects. It can penetrate into cells, strengthen cell metabolism, and activate the ability to tightly bind between cells. On the other hand, the elastic network structure of the epidermal layer can really repair wrinkles caused by water loss and achieve real moisturizing effect.
Features: It can repair skin with imperfect keratin, such as thin skin or keratin atrophy caused by medicated cosmetics. It can be used for 3-6 months to improve.
It can be used to increase the absorption of active ingredients and increase the resistance of cells, the effect is the most perfect, and it can improve the skin dehydration problem more thoroughly. Coenzyme Q10 is anti-oxidant, can eliminate free radicals and maintain the integrity and stability of cell membranes.
8, Protect the heart
Coenzyme Q-10 helps to provide sufficient oxygen to the heart muscle to prevent sudden heart disease. Coenzyme Q10 plays a key role in the process of myocardial hypoxia.
9, Auxiliary drugs
Statins inhibit the synthesis of cholesterol while also inhibiting the production of coenzyme Q10 in the body. Elderly patients are more likely to suffer from insufficient coenzyme Q10 in the patient's body. When using statins, coenzyme Q10 must be supplemented at the same time. It can quickly relieve myalgia and fatigue caused by statins to counteract myalgia and liver damage related to statins.
10, Boost energy
Experiments have shown that Coenzyme Q10 can greatly promote heart health, and the appropriate amount of Coenzyme Q10 in the human body is necessary for proper muscle function. Biochemical analysis of muscle cell extracts found that when the concentration of coenzyme Q10 was lower than 20% of normal, the work activities of mitochondrial complex I+II and complex I+III of the cells were severely decreased. Several studies have clearly shown that supplementation of Coenzyme Q10 at 100-150mg/day can significantly improve the condition of people suffering from muscular dystrophy. Hard physical exercise reduces the blood content of Coenzyme Q10, and daily supplementation of 60mg has been found to improve athletes’ skills. Many overweight people have very low levels of Coenzyme Q10, and supplementation can make them lose weight. This is because the role of Coenzyme Q10 can accelerate the metabolism of fat, make the limbs and brain energy supply abundant, and energetic.
11, Applicable symptoms
Coenzyme Q10 is used in the adjuvant treatment of the following diseases
1. Cardiovascular diseases, such as: viral myocarditis, chronic cardiac insufficiency.
2. Hepatitis, such as: viral hepatitis, subacute liver necrosis, chronic active hepatitis.
3. Comprehensive treatment of cancer: it can alleviate certain adverse reactions caused by radiotherapy and chemotherapy.
12, Content and usage
Body content
The total content of Coenzyme Q10 in the human body is only 500-1500mg and decreases with age. The content of coenzyme Q10 in human organs reaches a peak at the age of 20, and then rapidly decreases. The decrease in the concentration of Coenzyme Q10 in the heart is particularly pronounced. The 77-year-old man had 57% less coenzyme Q10 in the myocardium than the 20-year-old man.
| Food |
Content of Coenzyme Q10 |
Food |
Content of Coenzyme Q10 |
| sardine |
33.6 |
corn |
6.9 |
| Saury |
26.8 |
brown rice |
5.4 |
| pig heart |
25.6 |
spinach |
5.1 |
| Pork liver |
25.1 |
vegetables |
3.2 |
| Black fish |
25.1 |
rape |
2.7 |
| Pork loin |
24.7 |
carrot |
2.6 |
| Salmon |
22.5 |
lettuce |
2.5 |
| mackerel |
21.8 |
tomato |
2.5 |
| beef |
21.2 |
Kiwi |
2.4 |
| pork |
16.1 |
celery |
2.3 |
| peanut |
11.3 |
sweet potato |
2.3 |
| broccoli |
10.8 |
orange |
2.3 |
| Cherry |
10.7 |
eggplant |
2.3 |
| barley |
10.6 |
pea |
2.0 |
| soy |
7.3 |
Lotus root |
1.3 |
13, Supplement dose
Some experts engaged in research with coenzyme Q10 believe that many people, especially the elderly and those engaged in intense exercise, will lack coenzyme Q10 and can benefit from supplementation, indicating that coenzyme Q10 is the only fat-soluble antioxidant synthesized in the body. Aging, anti-fatigue and maintaining the body's youth and vitality. The recommended daily dose for health maintenance is 30 mg: quite high amounts are needed in the treatment of various diseases, and benefits have been found for supplementation. Coenzyme Q10 should be taken with a diet containing fat, and even better combined with soybean oil or vegetable oil, which can increase its complete and substantial absorption. The human body can quickly absorb the supplement of Coenzyme Q10. Daily doses of up to 400 mg have been reported. The researcher said: "Vitamin-like coenzyme Q10 may be the "guide" of cell and biochemical treatments in the new century. It is a supplement and extension of current medical methods." Nowadays, developed countries such as Europe, America and Japan have taken the level of coenzyme Q10 in the human body as one of the important indicators to measure physical health.
14, Who should take Coenzyme Q10
Athletes, mental workers, and people with poor immunity will benefit from appropriate supplementation of Coenzyme Q10; patients with heart disease, periodontitis, gastric ulcers, Alzheimer's disease, and diabetes can help to improve their condition by supplementing Japanese esmay coenzyme Q10; gum bleeding In severe cases, in addition to supplementing vitamin C, you should also take more coenzyme Q10.
