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Sialic Acid

Sialic Acid has the functions of improving infants’ intelligence and memory, resisting Alzheimer’s disease, resisting recognition, improving the absorption of vitamins and minerals in the intestine, antibacterial detoxification and antiviral.
 
Product parameters
Trade Name: Cosroma® NA
Product Name: Sialic Acid
Other Names: N-Acetylneuraminic acid
CAS No.: 131-48-6
Form: Powder
Assay: 98%min
Certification: ISO9001; ISO 14001; ISO 18001
Packing Sizes: 25KG
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Description
Sialic Acid
 
In 1957, Blix et al. used a weak acid hydrolysis method to isolate a purple substance that reacted with Bia's reagent from the salivary gland mucin, and named it Sialic Acid (SA). In 1960, the chemical structure of Sialic Acid was accurately resolved by researchers. Sialic Acid is a general term for a class of acidic amino sugars with 9 carbon atoms and a pyranose structure. It is systematically named 5-amino-3,5-dideoxy-D-glycerol-D-galactononulose. Sialic Acid is widely distributed in nature. It has been found that many organisms have Sialic Acid. At present, there are more than 50 kinds of Sialic Acid, most of which are 5-acetamido-3,5-dideoxy-D- Derivatives of glycerol-D-galactononulose (Neu5Ac) and 2-keto-3-deoxy-D-glycerol-D-galactononulose (KDN) (Figure 1). N-acetyl-D-neuraminic acid (Neu5Ac or NeuAc) is the main type of Sialic Acid, and its content accounts for more than 99% of the entire Sialic Acid family, so the commonly referred to as Sialic Acid mostly refers to Neu5Ac, usually with α- The glycoside form is located at the end of non-reducing oligosaccharides such as glycoproteins and glycolipids.
 
1. The physiological function of Sialic Acid
Sialic Acid has the functions of improving infantsintelligence and memory, resisting Alzheimers disease, resisting recognition, improving the absorption of vitamins and minerals in the intestine, antibacterial detoxification and antiviral.
 
1.1 Improve infant intelligence and memory.
Sialic Acid is an important component of brain gangliosides. The content of Sialic Acid in nerve cell membrane is 20 times that of other cells. Because brain information transmission and nerve impulse transmission must be realized through synapses, saliva Acid is a brain nutrient that acts on brain cell membranes and synapses, so Sialic Acid can promote the development of memory and intelligence. Research by Bing Wang et al. found that increasing the Sialic Acid content in the diet of suckling pigs in mammals increases the Sialic Acid content in the brain and the expression level of learning-related genes, thereby enhancing learning and memory capabilities. In babies, the content of Sialic Acid is only 25% of the content in breast milk. Since Sialic Acid is synthesized in the liver, in early childhood development, the brain develops quickly but the liver develops very slowly. The Sialic Acid synthesized by the liver can hardly meet the needs of brain development. Therefore, Sialic Acid is especially needed during infancy.
 
1.2 Anti-Alzheimer's
Sialic Acid has a high content in the human brain, which is related to the growth of nerve cells. The Sialic Acid on the cell surface protects cells and macromolecules from the attack of enzymes and the immune system, which is a manifestation of internal immunity. However, the content of Sialic Acid in the brain or blood of patients with neurological diseases such as Alzheimer's and schizophrenia decreases. After drug treatment, the content of Sialic Acid returns to normal, which indicates that Sialic Acid participates in nerve activity.
 
1.3 Anti-recognition and improve the absorption of vitamins and minerals in the intestine. Sialic Acid has a very strong negative charge. It is usually located at the end of the glycoprotein or glycolipid on the surface of the cell membrane and is the main source of negative charge on the cell membrane. The negative charge of Sialic Acid makes red blood cells and other cells repel each other, avoiding meaningless cell interactions in blood circulation. According to the principle of opposite sex attraction, the positively charged minerals (such as Ca2+) and some vitamins (such as the extremely small amount of vitamin B12 contained in food) that enter the intestine can easily interact with the highly negatively charged saliva The acid binds together. Therefore, Sialic Acid can increase the intestinal tract's ability to absorb minerals and vitamins, and supplementation of Sialic Acid can enhance the body's absorption of nutrients.
 
1.4 Antibacterial detoxification and antiviral.
Due to the special structure of the 9-carbon amino sugar of
Sialic Acid molecule, there is no enzyme in the digestive tract system that degrades the substance. Therefore, the formed polypeptide combination will not be affected by the digestive tract enzymes when passing through the digestive system. It is degraded and then enters the intestine. In the intestine, the specific Sialic Acid peptide conjugate can form a competitive binding with pathogenic bacteria, toxins and virus particles entering the intestine, thereby preventing intestinal toxins, pathogenic bacteria and virus particles. Binding with intestinal mucosal cells. It can be seen that adding Sialic Acid to food can improve the antibacterial, detoxification and antiviral capabilities of the intestinal tract.
 
2. The application of Sialic Acid
With more and more researches on the biological functions of Sialic Acid by scientific researchers, the study of the biological activity of Sialic Acid has become a new research field. Sialic Acid and its derivatives have a wide range of applications in food, medicine and disease diagnosis. .
 
2.1 The application of Sialic Acid in the food field.
Because the liver of newborns is not mature yet,
Sialic Acid is needed for the rapid growth and development of the brain, and the ability of the newborn to synthesize Sialic Acid is limited, so Sialic Acid needs to be supplemented to meet the needs of infant growth and development. Studies have found that supplementing exogenous Sialic Acid through diet can increase the content of Sialic Acid in the brain, which indicates that Sialic Acid can be added to infant milk powder to effectively promote their nervous system and brain development, and at the same time affect their intelligence development. Mead Johnson recognizes that the lower Sialic Acid content in infant formula milk powder is worthy of improvement, and has seized this opportunity to increase the content of Sialic Acid in its formula milk powder to bring it closer to the gold standard of breast milk. Add Sialic Acid and Sialic Acid derivatives to beverages to make a functional beverage. Long-term drinking of beverages can not only prevent colds, but also increase the intestinal absorption capacity of vitamins and minerals, and improve brain learning ability. , Helps to improve physical fitness.
 
2.2 The application of Sialic Acid in the field of medicine.
With the study of
Sialic Acid, researchers have found that Sialic Acid and its derivatives can inhibit sialidase and anti-influenza virus, anti-parainfluenza virus, anti-rotavirus, and anti-respiratory tract synergy. Cytovirus and anti-adenovirus have important roles. At present, anti-influenza drugs developed with Sialic Acid as a precursor have become a research hotspot.
 
2.3 The application of Sialic Acid in disease diagnosis
The liver is an important organ for protein and fat metabolism. At the same time, the connection of
Sialic Acid to the end of the sugar chain is also carried out in the liver. Therefore, it can be inferred that liver disease will affect the level of Sialic Acid in the body. The liver secretes a large amount of glycoproteins into the blood, and Sialic Acid is linked to the ends of these sugar chains. This Sialic Acid can ensure the stable existence of serum proteins. Serum Sialic Acid has been discovered in recent years as a serum marker for the diagnosis of primary liver cancer, and it is receiving increasing attention from clinical research. Liver cirrhosis is a high-risk group of liver cancer, and the detection of serum Sialic Acid levels has certain value in the diagnosis and prevention of liver cirrhosis. Malignant tumor cell membrane molecules often exhibit glycosylation, which plays an important role in cell recognition, adhesion, inflammation, and tumor cell metastasis. It has been found that serum Sialic Acid is significantly elevated in patients with various tumors such as melanoma, and is the highest in advanced tumors. Therefore, Sialic Acid can be used as an important marker for tumor diagnosis.